• Boy on a stick and Slither: http://www.boasas.com/ - Funnier than most.
• Wigu: http://www.wigu.com/ - Actually, Wigu ended, and was replaced with The TV Network Channel. Both are hilarious in a very idiosyncratic fashion.

Are we talking just-web-comics here, or comics-that-are-on-the-web? Because in the latter case, one would have to mention Maakies (http://www.maakies.com/), Underworld (http://www.kazunderworld.com/), Bob the Angry Flower (http://www.angryflower.com/), &c, &c.