I love 4-ch, and I read it a lot at work. Sometimes, it's just too much and I can't help but laugh out loud, then of course my colleague will say "What are you laughing at?"
Now, I've thought about just telling her, but I don't think she'd understand me when I say "Grandpa was talking about his funaral on DQN and giko cat said itteyoshi~!" So normally I just make something up and say "I'm laughing at some silly joke."
What about you? Have you ever had to explain 4-ch to someone?