The Nodame Cantabile anime is coming up this winter season. If it's as good as the drama it'll be a must-see.

The Animation Runner Kuromi OVAs also come to mind, although they lean towards exagerrated slapstick.

Are you too lazy to read manga in general? The genre is a lot less popular in animation, so there's a lot more of this type of story in print. For example, Living Game, about a guy in a struggling small company and his eccentric co-workers. The whole story has been scanlated.